Vanderbilt University Medical Center, Nashville, TN 37203-1738, USA.
J Clin Oncol. 2013 Apr 20;31(12):1548-53. doi: 10.1200/JCO.2012.43.0942. Epub 2013 Mar 25.
We recently reported an inverse association between soy food intake and lung cancer risk among nonsmoking women. The effect size for aggressive lung cancers was larger than that observed for other types of lung cancer. Therefore, we hypothesized that soy consumption may favorably affect the overall survival of patients with lung cancer.
This analysis included 444 women with incident lung cancer identified from the Shanghai Women's Health Study. Prediagnosis soy food intake was assessed at enrollment and reassessed 2 years later. Proportional hazards models were used to evaluate the association between soy food intake and overall survival.
Of the 444 patients with lung cancer, 318 died during follow-up. Initial analyses including all patients showed that higher intake of soy food was associated with better overall survival after adjusting for demographic and lifestyle characteristics and other nonclinical factors. Larger effect sizes for the association were found after additional adjustment for tumor stage and treatment in analyses including 301 patients with data available on these clinical factors. Compared with the median intake of soy food, fully adjusted hazard ratios for total mortality associated with the 10th, 30th, 70th, and 90th percentiles of intake were 1.81 (95% CI, 1.26 to 2.59), 1.25 (95% CI, 1.09 to 1.42), 0.88 (95% CI, 0.80 to 0.97), and 0.89 (95% CI, 0.68 to 1.16), respectively. Similar inverse associations were observed for dietary isoflavone intake.
This study suggests, to the best of our knowledge for the first time, that, among women with lung cancer, prediagnosis intake of soy food is associated with better overall survival.
我们最近报告了非吸烟女性的大豆食品摄入量与肺癌风险之间呈负相关。侵袭性肺癌的效应大小大于其他类型肺癌的观察结果。因此，我们假设大豆的摄入可能对肺癌患者的总生存率产生有利影响。
本分析包括从上海妇女健康研究中确定的 444 名患有肺癌的女性。在入组时评估了发病前大豆食品的摄入量，并在 2 年后再次评估。使用比例风险模型来评估大豆食品摄入量与总生存率之间的关系。
在 444 名肺癌患者中，318 人在随访期间死亡。包括所有患者的初始分析表明，在调整人口统计学和生活方式特征以及其他非临床因素后，大豆食品摄入量较高与总体生存率较好相关。在包括 301 名有这些临床因素数据的患者的分析中，对肿瘤分期和治疗进行了额外调整后，发现了该关联的更大效应大小。与大豆食品中位数摄入量相比，摄入量第 10、30、70 和 90 百分位数与总死亡率相关的完全调整后的危险比分别为 1.81（95%CI，1.26 至 2.59）、1.25（95%CI，1.09 至 1.42）、0.88（95%CI，0.80 至 0.97）和 0.89（95%CI，0.68 至 1.16）。膳食异黄酮摄入量也观察到了类似的反比关系。
就我们所知，这是首次研究表明，在患有肺癌的女性中，发病前摄入大豆食品与更好的总生存率相关。
