New York Center for Voice and Swallowing Disorders, St. Luke's Roosevelt Medical Center, New York, New York, U.S.A.
Laryngoscope. 2013 Oct;123(10):2497-501. doi: 10.1002/lary.24073. Epub 2013 Apr 1.
OBJECTIVES/HYPOTHESIS: 1) To clarify essential voice tremor (EVT) phenomenology; 2) To report a management paradigm for essential voice tremor using botulinum toxin.
Retrospective analysis of prospectively collected data.
Phenomenology from patients diagnosed with EVT between April 1996 and March 2012 was recorded, charted, and analyzed. A paradigm for treatment of EVT using botulinum toxin based on individualized clinical findings is discussed.
Sixteen patients were included. Fewer than 50% patients were responsive to centrally acting oral medications. Fifteen patients analyzed had horizontal laryngeal tremor and received botulinum toxin injections to bilateral thyroarytenoid muscles. Thirteen patients had a vertical laryngeal tremor, and these patients underwent additional strap muscle injections. All patients had symptomatic improvement with reduced tremor amplitude. Dose adjustments over time depended on degree of symptomatic improvement.
Management of essential voice tremor with botulinum toxin is optimized by individualizing treatment based on the tremor phenomenology observed during clinical examination.
目的/假设：1）阐明特发性声带震颤（EVT）的现象学；2）报告使用肉毒毒素治疗特发性声带震颤的管理模式。
前瞻性收集数据的回顾性分析。
记录、图表和分析 1996 年 4 月至 2012 年 3 月期间诊断为 EVT 的患者的现象学。讨论了一种基于个体化临床发现的使用肉毒毒素治疗 EVT 的范例。
共纳入 16 例患者。少于 50%的患者对中枢作用的口服药物有反应。分析的 15 例患者有水平性声带震颤，并接受了双侧甲状软骨肌肉毒毒素注射。13 例患者有垂直性声带震颤，这些患者接受了额外的带状肌注射。所有患者的症状均有改善，震颤幅度降低。随着时间的推移，剂量调整取决于症状改善的程度。
根据临床检查中观察到的震颤现象学，个体化治疗特发性声带震颤的肉毒毒素治疗效果最佳。
4。
