Kishi Taro, Fukuo Yasuhisa, Okochi Tomo, Kawashima Kunihiro, Moriwaki Masatsugu, Furukawa Osamu, Musso Giovanna M, Fujita Kiyoshi, Correll Christoph U, Iwata Nakao
Division of Psychiatry Research, The Zucker Hillside Hospital, Glen Oaks, NY, USA.
Hum Psychopharmacol. 2013 May;28(3):220-9. doi: 10.1002/hup.2310. Epub 2013 Apr 4.
We investigated whether nicotine dependence affects these endophenotypes in Japanese schizophrenia patients and whether alpha4 and beta2 subunits of neuronal nicotinic acetylcholine receptor genes (alpha4 subunit of the nAChR gene (CHRNA4)/beta2 subunit of the nAChR gene (CHRNB2)) were associated with nicotine dependence in patients (n = 100) and healthy controls (n = 107).
First, in patients, we evaluated cognitive function, using the Brief Assessment of Cognition in Schizophrenia, and acoustic startle responses. Second, we evaluated the severity of nicotine dependence, using the Tobacco Dependence Screener, the Fagerström Test for Nicotine Dependence, and the Brinkman index in current smokers in both groups. Third, we evaluated the relationship between acoustic startle responses, cognitive function, and severity of nicotine dependence. Finally, using 12 tagging single-nucleotide polymorphisms in each the CHRNA4/CHRNB2, we used multiple linear regression analysis to examine the association between nicotine dependence measures and each selected single-nucleotide polymorphism.
The presence and severity of nicotine dependence were associated with verbal memory and executive function in schizophrenia patients. However, nicotine dependence was not correlated with any acoustic startle response. In addition, rs755203 and rs1044397 in CHRNA4 were associated with nicotine dependence in healthy controls.
Nicotine dependence might influence the level of verbal memory and executive function in schizophrenia patients. In addition, rs755203 and rs1044397 in CHRNA4 might play a role in the pathophysiology of nicotine dependence in healthy controls in the Japanese population.
我们调查了尼古丁依赖是否会影响日本精神分裂症患者的这些内表型，以及神经元烟碱型乙酰胆碱受体基因的α4和β2亚基（烟碱型乙酰胆碱受体基因（CHRNA4）的α4亚基/烟碱型乙酰胆碱受体基因（CHRNB2）的β2亚基）是否与患者（n = 100）和健康对照者（n = 107）的尼古丁依赖有关。
首先，在患者中，我们使用精神分裂症认知功能简短评估量表评估认知功能，并测量听觉惊吓反应。其次，我们使用烟草依赖筛查量表、尼古丁依赖Fagerström测试和Brinkman指数评估两组当前吸烟者的尼古丁依赖严重程度。第三，我们评估听觉惊吓反应、认知功能与尼古丁依赖严重程度之间的关系。最后，我们在CHRNA4/CHRNB2中使用12个标签单核苷酸多态性，采用多元线性回归分析来检验尼古丁依赖测量指标与每个选定单核苷酸多态性之间的关联。
尼古丁依赖的存在和严重程度与精神分裂症患者的言语记忆和执行功能有关。然而，尼古丁依赖与任何听觉惊吓反应均无相关性。此外，CHRNA4中的rs755203和rs1044397与健康对照者的尼古丁依赖有关。
尼古丁依赖可能会影响精神分裂症患者的言语记忆水平和执行功能。此外，CHRNA4中的rs755203和rs1044397可能在日本人群健康对照者尼古丁依赖的病理生理学中发挥作用。
