Laboratorio de Hematobiología, Escuela Nacional de Medicina y Homeopatía ENMH, Instituto Politécnico Nacional IPN, Mexico City, Mexico.
J Cell Biochem. 2013 Sep;114(9):2050-60. doi: 10.1002/jcb.24546.
The role of platelets in coagulation and the haemostatic process was initially suggested two centuries ago, and under appropriate physiological stimuli, these undergo abrupt morphological changes, attaching and spreading on damaged endothelium, preventing bleeding. During the adhesion process, platelet cytoskeleton reorganizes generating compartments in which actin filaments, microtubules, and associated proteins are arranged in characteristic patterns mediating crucial events, such as centralization of their organelles, secretion of granule contents, aggregation with one another to form a haemostatic plug, and retraction of these aggregates. However, the role of Intermediate filaments during the platelet adhesion process has not been explored. J. Cell. Biochem. 114: 2050-2060, 2013. © 2013 Wiley Periodicals, Inc.
两百多年前，人们就提出了血小板在凝血和止血过程中的作用。在适当的生理刺激下，血小板发生急剧的形态变化，附着并铺展在受损的内皮细胞上，防止出血。在黏附过程中，血小板细胞骨架重新排列，形成隔室，其中肌动蛋白丝、微管和相关蛋白以特征性的模式排列，介导重要事件，如细胞器的集中、颗粒内容物的分泌、彼此聚集形成止血栓，以及这些聚集物的回缩。然而，中间丝在血小板黏附过程中的作用尚未得到探索。《细胞与生化杂志》114:2050-2060, 2013。©2013 年 Wiley Periodicals, Inc.
