Department of Psychology, Kent State University, Kent, OH, USA.
CNS Spectr. 2013 Apr;18(2):103-11. doi: 10.1017/S1092852913000096.
OBJECTIVE/INTRODUCTION: Secondary pharmacological interventions have shown promise at reducing the development of posttraumatic stress disorder symptoms (PTSS) in preclinical studies. The present study examined the preliminary efficacy of a 10-day low-dose (20 mg bid) course of hydrocortisone at preventing PTSS in traumatic injury victims.
Sixty-four traumatic injury patients (34% female) were randomly assigned in a double-blind protocol to receive either a 10-day course of hydrocortisone or placebo initiated within 12 hours of the trauma. One-month and 3-months posttrauma participants completed an interview to assess PTSS and self-report measures of depression and health-related quality of life.
Hydrocortisone recipients reported fewer PTSD and depression symptoms, and had greater improvements in health-related quality of life during the first 3 months posttrauma than did placebo recipients. Hydrocortisone recipients who had never received prior mental health treatment had the lowest PTSD scores.
Low-dose hydrocortisone may be a promising approach to the prevention of PTSD in acutely injured trauma patients, and may be particularly efficacious in acutely injured trauma victims without a history of significant psychopathology.
目的/介绍：在临床前研究中，继发性药物干预已显示出减少创伤后应激障碍症状（PTSS）发展的潜力。本研究探讨了为期 10 天低剂量（20mg，bid）氢化可的松预防创伤性损伤患者 PTSD 的初步疗效。
64 名创伤性损伤患者（34%为女性）按双盲方案随机分配，在创伤后 12 小时内接受为期 10 天的氢化可的松或安慰剂治疗。创伤后 1 个月和 3 个月，参与者完成访谈以评估 PTSD 和抑郁自评量表以及健康相关生活质量。
与安慰剂组相比，接受氢化可的松治疗的患者 PTSD 和抑郁症状较少，在创伤后 3 个月内健康相关生活质量改善更大。从未接受过心理健康治疗的氢化可的松组患者 PTSD 评分最低。
低剂量氢化可的松可能是预防急性创伤性损伤患者 PTSD 的一种有前途的方法，对于没有明显精神病史的急性创伤性损伤患者可能特别有效。
