Department of Anesthesiology and Pain Medicine, University of Texas Southwestern Medical Center Dallas and Children's Medical Center at Dallas, 1935 Medical District Drive, Dallas, TX 75235, USA.
Anesth Analg. 2013 Jun;116(6):1309-13. doi: 10.1213/ANE.0b013e31828d3730. Epub 2013 Apr 4.
Intraoperative intraocular pressure (IOP) in the prone position and IOP changes over time have not been evaluated in pediatric surgical patients. We sought to determine time-dependent changes in IOP in children undergoing surgery in prone position.
Thirty patients undergoing neurosurgical procedures in prone position were included. Using a pulse-mode pneumatonometer, IOP was measured in supine position after induction and before emergence of anesthesia and in prone position before the start and after the end of surgery. IOP changes over time in the prone position were assessed with a linear mixed model (i.e., random slope and intercept model) to adjust for the within-patient correlation.
IOP in prone position increased by an average of 2.2 mm Hg per hour (P < 0.001). Sixty-three percent of patients (95% confidence interval [CI], 46%-81%) had at least 1 IOP value exceeding 30 mm Hg, and 13% (95% CI, 1%-25%) had at least 1 IOP value exceeding 40 mm Hg while prone. Mean IOP increased 7 mm Hg (95% CI, 6-9) during the position change from supine to prone (P < 0.001) and decreased 10 mm Hg (95% CI, 9-12) after changing the position from prone back to supine (P < 0.001).
Changing position from supine to prone significantly increases IOP in anesthetized pediatric patients. Moreover, the IOP continued to increase during surgery and reached potentially harmful values, especially when combined with low mean arterial blood pressures that are common during major surgery.
在儿科手术患者中,尚未评估俯卧位时的术中眼内压(IOP)和随时间的 IOP 变化。我们旨在确定俯卧位手术儿童的 IOP 随时间的变化。
纳入 30 例行神经外科手术的俯卧位患者。使用脉冲模式眼压计,在麻醉诱导后和苏醒前测量仰卧位时的 IOP,以及在手术开始前和结束后测量俯卧位时的 IOP。使用线性混合模型(即随机斜率和截距模型)评估俯卧位时的 IOP 随时间的变化,以调整患者内相关性。
俯卧位时的 IOP 平均每小时增加 2.2mmHg(P<0.001)。63%的患者(95%置信区间[CI],46%-81%)至少有 1 个 IOP 值超过 30mmHg,13%(95%CI,1%-25%)至少有 1 个 IOP 值超过 40mmHg。从仰卧位变为俯卧位时,平均 IOP 增加 7mmHg(95%CI,6-9)(P<0.001),从俯卧位变为仰卧位后,平均 IOP 降低 10mmHg(95%CI,9-12)(P<0.001)。
在麻醉的儿科患者中,从仰卧位变为俯卧位会显著增加 IOP。此外,IOP 在手术过程中持续增加,并达到潜在有害的水平,尤其是在大型手术中常见的平均动脉血压较低时。