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白细胞增多后急性髓系白血病患儿的慢性硬膜下血肿

Chronic subdural hematoma in a child with acute myeloid leukemia after leukocytosis.

作者信息

Basmaci Mehmet, Hasturk Askin E

机构信息

Department of Neurosurgery, Dr. Abdurrahman Yurtaslan Oncology Training and Research Hospital, Ankara, Turkey.

出版信息

Indian J Crit Care Med. 2012 Oct;16(4):222-4. doi: 10.4103/0972-5229.106508.

Abstract

Severe complications that develop in the early stages in patients with acute leukemia have a mortal course. Bleeding, leukostasis, and less frequently, infections are responsible for early mortality. Hemorrhage is most common in acute leukemia and usually leads to death. Hemorrhage may occur due to chemotherapy or bone marrow transplantation in patients with acute leukemia. Leukocytosis, thrombocytopenia, sepsis, and coagulopathy increase the risk of bleeding. There may be multiple etiologic factors. Subdural or subarachnoid hemorrhage is less common than an intra-axial hemorrhage. The incidence of spontaneous subdural hematoma is higher in patients with leukemia. Although advances in the treatment of platelet transfusion and disseminated intravascular coagulation have decreased the incidence of hemorrhagic complications in patients receiving chemotherapy for acute leukemia, intracranial hemorrhage-related deaths are a significant problem. We discussed the etiology and management of chronic subdural hematoma detected in a two-year-old male patient with Acute Myeloid Leukemia and hyperleukocytosis.

摘要

急性白血病患者早期出现的严重并发症病程凶险。出血、白细胞淤滞,较少见的还有感染是早期死亡的原因。出血在急性白血病中最为常见,通常会导致死亡。急性白血病患者出血可能是由于化疗或骨髓移植引起的。白细胞增多、血小板减少、败血症和凝血病会增加出血风险。可能存在多种病因。硬膜下或蛛网膜下腔出血比轴内出血少见。白血病患者自发性硬膜下血肿的发生率较高。尽管血小板输注和弥散性血管内凝血治疗的进展降低了接受急性白血病化疗患者出血并发症的发生率,但颅内出血相关死亡仍是一个重大问题。我们讨论了一名两岁急性髓系白血病合并白细胞增多症男性患者中发现的慢性硬膜下血肿的病因及处理。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a00/3610458/93b82f7544a9/IJCCM-16-222-g001.jpg

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