如果干细胞在隐窝中死亡，而周围没有人看到它……
If a stem cell dies in the crypt, and no one is around to see it….
机构信息
Biomedical Sciences Graduate Program, Program in Craniofacial and Mesenchymal Biology, University of California, San Francisco, San Francisco, CA 94143, USA.
出版信息
Cell Stem Cell. 2013 Apr 4;12(4):389-90. doi: 10.1016/j.stem.2013.03.009.
PMID:23561439
Abstract
Two recent studies continue the debate regarding lineage and hierarchy in the intestinal epithelium. One reports that quiescent crypt cells are Paneth cell precursors (Buczacki et al., 2013). The second shows that tamoxifen induces apoptosis in crypt cells and that suppressing apoptosis alters lineage tracing patterns (Zhu et al., 2013).
摘要
两项最近的研究继续探讨了肠道上皮细胞谱系和层次结构的问题。其中一项研究报告称，静止的隐窝细胞是 Paneth 细胞前体（Buczacki 等人，2013 年）。另一项研究表明，他莫昔芬可诱导隐窝细胞凋亡，而抑制凋亡会改变谱系追踪模式（Zhu 等人，2013 年）。
Zotero 插件