糖尿病的干细胞治疗。
Stem cell therapy for diabetes.
作者信息
Lee K O, Gan S U, Calne R Y
机构信息
Department of Medicine, National University of Singapore, Singapore.
出版信息
Indian J Endocrinol Metab. 2012 Dec;16(Suppl 2):S227-9. doi: 10.4103/2230-8210.104045.
Stem cell therapy holds immense promise for the treatment of patients with diabetes mellitus. Research on the ability of human embryonic stem cells to differentiate into islet cells has defined the developmental stages and transcription factors involved in this process. However, the clinical applications of human embryonic stem cells are limited by ethical concerns, as well as the potential for teratoma formation. As a consequence, alternative forms of stem cell therapies, such as induced pluripotent stem cells, umbilical cord stem cells and bone marrow-derived mesenchymal stem cells, have become an area of intense study. Recent advances in stem cell therapy may turn this into a realistic treatment for diabetes in the near future.
干细胞疗法在治疗糖尿病患者方面具有巨大的前景。对人类胚胎干细胞分化为胰岛细胞能力的研究已经明确了这一过程中涉及的发育阶段和转录因子。然而，人类胚胎干细胞的临床应用受到伦理问题以及畸胎瘤形成可能性的限制。因此，诸如诱导多能干细胞、脐带干细胞和骨髓来源的间充质干细胞等替代形式的干细胞疗法已成为一个深入研究的领域。干细胞疗法的最新进展可能会在不久的将来使其成为糖尿病的一种切实可行的治疗方法。
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