通过碳酸铵盐实现有机催化的 Knoevenagel 缩合反应。
Organocatalytic Knoevenagel condensations by means of carbamic acid ammonium salts.
机构信息
Department of Molecular Science, Faculty of Engineering, Shizuoka University, 3-5-1 Johoku, Hamamatsu 432-8561, Japan.
出版信息
Org Lett. 2013 Apr 19;15(8):1854-7. doi: 10.1021/ol400462d. Epub 2013 Apr 8.
The Knoevenagel condensation between an active methylene compound and an aromatic aldehyde with a carbamic acid ammonium salt used as an organocatalyst gave the desired Knoevenagel products in up to 98% yield. The reaction occurred at rt and in a short reaction time under solvent-free conditions. In addition, no extraction, wash, or chromatography steps were needed to obtain a high-purity Knoevenagel product.
使用胍盐作为有机催化剂，通过活泼亚甲基化合物与芳香醛的 Knoevenagel 缩合反应，可以高产率（高达 98%）得到目标 Knoevenagel 产物。该反应在室温下、无溶剂条件下、短反应时间内即可进行。此外，无需萃取、洗涤或层析等步骤即可获得高纯度的 Knoevenagel 产物。
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