瞄准神经母细胞瘤并攻克其他有价值的靶点。
Aiming at neuroblastoma and hitting other worthy targets.
作者信息
Schor Nina F
机构信息
Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA.
出版信息
J Child Neurol. 2013 Jun;28(6):768-73. doi: 10.1177/0883073813483173. Epub 2013 Apr 10.
Abstract
Neuroblastoma is, at once, the most common and deadly extracranial solid tumor of childhood. Efforts aimed at targeting the neural characteristics of these tumors have taught us much about neural crest cell biology, apoptosis induction in the nervous system, and neurotrophin receptor signaling and intracellular processing. But neuroblastoma remains a formidable enemy to the oncologist and an enigmatic target to the neuroscientist.
摘要
神经母细胞瘤是儿童期最常见且致命的颅外实体瘤。针对这些肿瘤神经特性的研究，让我们对神经嵴细胞生物学、神经系统中的细胞凋亡诱导、神经营养因子受体信号传导及细胞内加工有了很多了解。但神经母细胞瘤对肿瘤学家而言仍是一个 formidable enemy，对神经科学家来说仍是一个 enigmatic target。 （注：原文中“formidable enemy”直译为“强大的敌人”，“enigmatic target”直译为“神秘的目标”，这里保留英文是因为在医学语境中可能更专业或特定，可根据实际情况进一步优化表述使其更符合中文习惯）
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