Veselska R, Skoda J, Neradil J
Laboratory of Tumor Biology, Department of Experimental Biology, School of Science, Masaryk University, Brno, Czech Republic.
Klin Onkol. 2012;25 Suppl 2:2S16-20.
The identification of cancer stem cell markers represents one of the very relevant research topics because cancer stem cells play important roles in tumour initiation and progression, as well as during metastasis formation and in relapse of the disease. This article summarises recent knowledge on well-known and putative cancer stem cell markers in various types of bone and soft-tissue sarcomas. Special attention is paid to the detection of CD133, ABC transporters, nestin and aldehyde dehydrogenase that have been intensively studied both in tumour tissues and in sarcoma cell lines during the past few years. Finally, an overview is given of the possible CSC phenotypes provided by functional assays of tumourigenicity.
癌症干细胞标志物的鉴定是非常重要的研究课题之一,因为癌症干细胞在肿瘤的起始和进展、转移形成以及疾病复发过程中都发挥着重要作用。本文总结了各类骨肉瘤和软组织肉瘤中已知及推测的癌症干细胞标志物的最新研究进展。特别关注了CD133、ABC转运蛋白、巢蛋白和醛脱氢酶的检测,在过去几年中,这些标志物在肿瘤组织和肉瘤细胞系中都得到了深入研究。最后,对通过肿瘤igenicity功能测定提供的可能的CSC表型进行了概述。