[大剂量甲氨蝶呤输注意外缩短时间：病例报告与文献综述]

[Accidental shortening time of high dose methotrexate infusion: case report and literature review].

作者信息

Charfi Rim, Salouage Issam, Trabelsi Sameh, Zarrouk Mohamed, Gaïes Emna, Jebabli Nadia, Meddeb Balkis, Lakhal Mohamed, Klouz Anis

机构信息

Service de pharmacologie clinique, Centre national de pharmacovigilance de Tunis, Tunisia.

出版信息

Ann Biol Clin (Paris). 2013 Mar-Apr;71(2):219-22. doi: 10.1684/abc.2013.0803.

DOI:10.1684/abc.2013.0803

PMID:23587592

Abstract

Methotrexate (MTX) is a folic acid antagonist used at high-dose intravenously on 24 hours (24h) in the treatment of the acute lymphoblastic leukemia (ALL). To prevent potential toxicity, MTX is usually administered following the application of preventive measures. We report a case of an accidental shortening time for high dose MTX infusion and a literature review of accidental intoxications by the MTX. This case illustrates the importance of the respect of MTX high dose infusion time and the major role played by the therapeutic drug monitoring.

摘要

甲氨蝶呤（MTX）是一种叶酸拮抗剂，用于大剂量静脉滴注24小时治疗急性淋巴细胞白血病（ALL）。为预防潜在毒性，MTX通常在采取预防措施后给药。我们报告一例大剂量MTX输注时间意外缩短的病例，并对MTX意外中毒进行文献综述。该病例说明了遵守MTX大剂量输注时间的重要性以及治疗药物监测所起的主要作用。