Dermatologic Clinic, Department of Medical Sciences, University of Turin, Italy.
G Ital Dermatol Venereol. 2013 Apr;148(2):197-201.
Regulatory T cells (Tregs) play a crucial role by maintaining the peripheral tolerance and inhibiting autoimmunity. In recent years, numerous autoimmune and immune-mediated diseases have been shown to present significant number depletion and/or function impairment of this subset. In the present study, we present a brief overview of the results obtained by our group in association with the centers belonging to the Italian Immunopathology Group, as to the expression levels and biological significance of circulating regulatory CD4+CD25+brightFOXP3+ T cells in a variety of immune-mediated skin diseases (such as psoriasis, scleroderma, bullous pemphigoid and GvHD), together with preliminary results achieved in patients with inflammatory bowel disease-related dermatoses. This review shows that this series of different cutaneous diseases characterised by an immune-mediated pathogenesis, share a significant down-regulation of circulating FOXP3+ Treg cells, whilst the treatment and the achievement of clinical response are generally associated with an opposite phenomenon with up-regulation of Treg cells. Future studies are mandatory to identify the effective role of these modifications in the disease pathogenesis as well as its relationship with the clinical response.
调节性 T 细胞（Tregs）通过维持外周耐受和抑制自身免疫发挥着关键作用。近年来，许多自身免疫和免疫介导的疾病已经表明，该亚群存在显著数量的耗竭和/或功能障碍。在本研究中，我们简要概述了我们小组与属于意大利免疫病理学组的中心联合获得的结果，即循环调节性 CD4+CD25+brightFOXP3+T 细胞在各种免疫介导的皮肤疾病（如银屑病、硬皮病、大疱性类天疱疮和移植物抗宿主病）中的表达水平和生物学意义，以及在炎症性肠病相关皮肤病患者中获得的初步结果。这篇综述表明，这一系列具有免疫介导发病机制的不同皮肤疾病，共同表现为循环 FOXP3+Treg 细胞的显著下调，而治疗和临床缓解通常与 Treg 细胞的上调相反。未来的研究对于确定这些变化在疾病发病机制中的有效作用以及其与临床反应的关系是必不可少的。
