实验性蛛网膜下腔出血后血-动脉壁屏障破坏的病因学
Etiology of the disruption in blood-arterial wall barrier following experimental subarachnoid hemorrhage.
作者信息
Nakagomi T, Kassell N F, Sasaki T, Lehman R M, Fujiwara S
机构信息
Department of Neurological Surgery, University of Tokyo Hospital, Japan.
出版信息
Surg Neurol. 1990 Jul;34(1):16-26. doi: 10.1016/0090-3019(90)90167-n.
Aneurysmal subarachnoid hemorrhage is associated with a sudden rise in intracranial pressure, acute arterial hypertension, and subarachnoid blood. The role that each of these factors may play in the development of the acute barrier disruption of the major cerebral arteries following subarachnoid hemorrhage was investigated in 42 rabbits. Horseradish peroxidase was given intravenously to assess the integrity of the barrier by transmission electron microscopy. Permeation of the tracer into the vessel was noted only in animals with increased intracranial pressure. A sudden rise in intracranial pressure is suggested to trigger acute barrier disruption following subarachnoid hemorrhage.
动脉瘤性蛛网膜下腔出血与颅内压突然升高、急性动脉高血压和蛛网膜下腔出血有关。在42只兔子中研究了这些因素中的每一个在蛛网膜下腔出血后大脑主要动脉急性屏障破坏发展中可能起的作用。通过静脉注射辣根过氧化物酶，利用透射电子显微镜评估屏障的完整性。仅在颅内压升高的动物中观察到示踪剂渗透到血管中。提示颅内压突然升高会引发蛛网膜下腔出血后的急性屏障破坏。
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