Edinburgh Delirium Research Group, Geriatric Medicine, Division of Health Sciences, School of Clinical Sciences, University of Edinburgh, Edinburgh, Midlothian, Scotland; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, Midlothian, Scotland.
Am J Geriatr Psychiatry. 2013 Dec;21(12):1239-43. doi: 10.1016/j.jagp.2012.12.024. Epub 2013 Apr 18.
Delirium is associated with an increased risk of long-term cognitive decline, suggesting the possibility of concurrent central nervous system (CNS) injury. S100B is a putative biomarker of CNS injury and elevated serum levels in delirium have been reported. Here we hypothesize that delirium is associated with raised concentrations of cerebrospinal fluid (CSF) S100B.
Forty-five patients with hip fracture aged over 60 and awaiting surgery under spinal anesthesia were assessed for delirium pre- and post-operatively. CSF S100B levels were measured in samples collected at the onset of surgery.
Participants with pre-operative delirium (N = 8) had elevated Log10 CSF S100B (mean: -0.156; SD: 0.238) compared with those without delirium (mean: -0.306; SD: 0.162), Student's t-test t = 2.18, df = 43, p = 0.035.
This study provides preliminary evidence of elevated CSF S100B in current delirium, consistent with findings in serum and with other studies showing elevated S100B in the presence of diverse forms of CNS injury.
谵妄与长期认知能力下降的风险增加相关，提示存在中枢神经系统（CNS）损伤的可能性。S100B 是 CNS 损伤的潜在生物标志物，有研究报告称谵妄患者血清 S100B 水平升高。本研究假设谵妄与脑脊液（CSF）S100B 浓度升高有关。
45 名年龄超过 60 岁、拟行椎管内麻醉下髋关节手术的患者在术前和术后进行谵妄评估。在手术开始时采集样本测量 CSF S100B 水平。
术前发生谵妄的患者（N=8）的 Log10 CSF S100B 水平（均值：-0.156；标准差：0.238）高于未发生谵妄的患者（均值：-0.306；标准差：0.162），Student's t 检验 t = 2.18，df = 43，p = 0.035。
本研究初步证实了当前谵妄患者 CSF S100B 升高，与血清中的发现一致，也与其他研究中 CNS 损伤不同形式存在时 S100B 升高的结果一致。
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