Department of Surgery; Institute for Public Health, Washington University in St. Louis, St. Louis, MO, USA.
Cancer Epidemiol Biomarkers Prev. 2013 Jun;22(6):1110-7. doi: 10.1158/1055-9965.EPI-13-0169. Epub 2013 Apr 19.
Few studies have shown that the association between mammographic breast density and breast cancer persists for up to 10 years after the mammogram. We investigated associations of percent density, absolute dense, and nondense areas with breast cancer risk according to the time since the mammogram.
This study included 1,028 incident breast cancer cases diagnosed within the Nurses' Health Study and 1,780 matched controls. Breast density was measured from digitized film images with computerized techniques. Information on breast cancer risk factors was obtained prospectively from the biennial questionnaires before the date of cancer diagnosis for cases and their matched controls. The data were analyzed with logistic regression.
Breast cancer risk increased with increasing percent density and increasing absolute dense area and decreased with increasing nondense area. In multivariate analysis, the magnitude of the association between percent density and breast cancer was similar when the time since the mammogram was <2, 2 to <5, and 5 to <10 years [density ≥50% vs.<10%: ORs, 3.12; 95% confidence interval (CI): 1.55-6.25, 5.35 (95% CI: 2.93-9.76), and 3.91 (95%CI: 2.22-6.88), respectively]. Similarly, the magnitude of association between quartiles of dense and nondense areas and breast cancer risk were similar across the time strata. We found no interactions between the time since the mammogram and breast density measures (Pinteraction > 0.05).
Patterns of the associations between percent density, absolute dense, and nondense area with breast cancer risk persist for up to 10 years after the mammogram.
A one-time density measure can be used for long-term breast cancer risk prediction.
很少有研究表明，在乳房 X 光检查后长达 10 年内，乳房密度与乳腺癌之间的关联仍然存在。我们根据乳房 X 光检查后的时间，研究了百分比密度、绝对致密和非致密区域与乳腺癌风险之间的关联。
本研究纳入了在护士健康研究中诊断出的 1028 例乳腺癌病例和 1780 例匹配对照。使用计算机技术从数字化胶片图像中测量乳房密度。通过病例及其匹配对照的两年一次的问卷，前瞻性地获取乳腺癌危险因素的信息。使用逻辑回归分析数据。
乳腺癌风险随着百分比密度、绝对致密区的增加而增加，随着非致密区的增加而降低。在多变量分析中，乳房 X 光检查后时间<2 年、2-<5 年和 5-<10 年时，百分比密度与乳腺癌之间的关联强度相似[密度≥50%与<10%：ORs，3.12；95%置信区间（CI）：1.55-6.25，5.35（95%CI：2.93-9.76）和 3.91（95%CI：2.22-6.88）]。同样，致密和非致密区域四分位数与乳腺癌风险之间的关联强度在各时间层之间相似。我们没有发现乳房 X 光检查后时间和乳房密度测量之间的交互作用（Pinteraction>0.05）。
百分比密度、绝对致密和非致密区与乳腺癌风险之间的关联模式在乳房 X 光检查后长达 10 年内仍然存在。
一次性密度测量可用于长期乳腺癌风险预测。
