葡萄糖输入触发的生物分子释放——传感和致动系统的生物电子偶联。
Biomolecular release triggered by glucose input--bioelectronic coupling of sensing and actuating systems.
机构信息
Department of Chemistry and Biomolecular Science, Clarkson University, Potsdam, NY 13699, USA.
出版信息
Chem Commun (Camb). 2013 May 25;49(42):4755-7. doi: 10.1039/c3cc42027b.
PMID:23604285
Abstract
A drug-mimicking release process was triggered by a glucose signal resulting in the formation of a negative potential on an electrode modified with PQQ-dependent glucose dehydrogenase. This electrode was coupled with another electrode coated with an Fe(+3)-crosslinked alginate polymer film, which was dissolved upon formation of the negative potential releasing entrapped species.
摘要
一种药物模拟释放过程被葡萄糖信号触发，导致与依赖吡咯喹啉醌的葡萄糖脱氢酶修饰的电极上形成负电势。该电极与另一个电极相连，该电极涂有 Fe(+3)-交联藻酸盐聚合物膜，当形成负电势时，该聚合物膜溶解并释放被包埋的物质。
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