Costopoulos Charis, Latib Azeem, Naganuma Toru, Sticchi Alessandro, Giannini Francesco, Colombo Antonio
Interventional Cardiology Unit, San Raffaele Scientific Institute, Milan, Italy.
Expert Rev Cardiovasc Ther. 2013 May;11(5):555-66. doi: 10.1586/erc.13.43.
The introduction of drug-eluting stents has revolutionized the treatment of coronary artery disease. First-generation stents, however, were associated with relatively high revascularization rates and the risk of stent thrombosis. This has led to a worldwide search for improvements in stent technology that will reduce adverse cardiac events following stent implantation while providing optimal treatment. Here, the authors discuss recent advances in stent technology from improvements in stent platform and stent polymer to newer mechanisms of drug delivery and the incorporation of proendothelizing agents. The authors also introduce some of the newly available stents and discuss the evidence associated with their use in clinical practice.
药物洗脱支架的引入彻底改变了冠状动脉疾病的治疗方式。然而,第一代支架与相对较高的血管再通率和支架血栓形成风险相关。这促使全球范围内寻求支架技术的改进,以降低支架植入后的不良心脏事件,同时提供最佳治疗。在此,作者们讨论了支架技术的最新进展,从支架平台和支架聚合物的改进到药物递送的新机制以及促内皮化剂的加入。作者们还介绍了一些新上市的支架,并讨论了与其在临床实践中使用相关的证据。