查耳酮：一类新型抗有丝分裂剂。
Chalcones: a new class of antimitotic agents.
作者信息
Edwards M L, Stemerick D M, Sunkara P S
机构信息
Merrell Dow Research Institute, Cincinnati, Ohio 45215.
出版信息
J Med Chem. 1990 Jul;33(7):1948-54. doi: 10.1021/jm00169a021.
PMID:2362275
Abstract
A series of chalcones was evaluated as antimitotic agents. One of these, (E)-1-(2,5-dimethoxyphenyl)-3-[4-(dimethylamino)phenyl]-2-methyl-2-pr open- 1-one) (73), was found to be an effective antimitotic agent at a concentration of 4 nM in an in vitro HeLa cell test system. When evaluated in experimental tumor models in vivo, this compound exhibited antitumor activity against L1210 leukemia and B16 melanoma.
摘要
一系列查耳酮被评估为抗有丝分裂剂。其中之一，（E）-1-（2,5-二甲氧基苯基）-3-[4-（二甲基氨基）苯基]-2-甲基-2-丙烯-1-酮（73），在体外HeLa细胞测试系统中，浓度为4 nM时被发现是一种有效的抗有丝分裂剂。在体内实验性肿瘤模型中进行评估时，该化合物对L1210白血病和B16黑色素瘤表现出抗肿瘤活性。
Zotero 插件