斑点状角膜营养不良的临床特征及活体共聚焦显微镜成像
Clinical features and in-vivo confocal microscopic imaging of fleck corneal dystrophy.
作者信息
Can Ertuğrul, Kan Emrah, Akgün Halil İbrahim
机构信息
Ondokuz Mayıs University, School of Medicine, Department of Ophthalmology, Samsun, Turkey.
出版信息
Semin Ophthalmol. 2013 Jul;28(4):239-41. doi: 10.3109/08820538.2012.760629. Epub 2013 Apr 29.
PURPOSE
To evaluate the value of in-vivo confocal microscopy (CM) in the diagnosis of Fleck corneal dystrophy.
METHODS
Case report and literature review. After complete eye examination of the patient, in-vivo CM was performed. The morphologies of the corneal layers were evaluated by in-vivo CM.
RESULTS
Slit-lamp examination revealed bilateral gray-white, oval or round discrete opacities in the stroma. Confocal microscopy showed hyper-reflective opacities in enlarged and unremarkable keratocyte nuclei throughout the stroma. The surface epithelium, subbasal nerves, and endothelium showed normal morphology.
CONCLUSION
The diagnosis of rare corneal dystrophies such as Fleck corneal dystrophy should sometimes be made only after performing in-vivo confocal microscopy.
目的
评估活体共聚焦显微镜（CM）在斑点状角膜营养不良诊断中的价值。
方法
病例报告及文献复习。对患者进行全面眼部检查后，进行活体共聚焦显微镜检查。通过活体共聚焦显微镜评估角膜各层的形态。
结果
裂隙灯检查显示基质层有双侧灰白色、椭圆形或圆形散在混浊。共聚焦显微镜检查显示整个基质层中角膜细胞的细胞核增大且不明显，有高反射性混浊。表面上皮、基底膜下神经和内皮细胞形态正常。
结论
对于罕见的角膜营养不良，如斑点状角膜营养不良，有时仅在进行活体共聚焦显微镜检查后才能做出诊断。
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