通过 Zr 介导的炔基硼酸酯的双重官能化和随后的 Ru 催化的闭环烯烃复分解反应合成环状 1-烯基硼酸酯。

Synthesis of cyclic 1-alkenylboronates via Zr-mediated double functionalization of alkynylboronates and sequential Ru-catalyzed ring-closing olefin metathesis.

机构信息

Division of Earth, Life, and Molecular Sciences, Graduate School of Natural Science and Technology, Okayama University , 3-1-1 Tsushimanaka, Kita-ku, Okayama 700-8530, Japan, and Japan Science and Technology Agency , ACT-C, 4-1-8 Honcho, Kawaguchi, Saitama 332-0012, Japan.

出版信息

Org Lett. 2013 May 17;15(10):2418-21. doi: 10.1021/ol400896u. Epub 2013 Apr 30.

DOI:10.1021/ol400896u

PMID:23631488

Abstract

Synthesis of novel cyclic 1-alkenylboronates is accomplished through the zirconium-mediated regio- and stereoselective double functionalization of 1-alkynylboronates and the subsequent ruthenium-catalyzed ring-closing metathesis (RCM). The obtained substituted cyclic 1-alkenylboronates are transformed into o-terphenyl and triphenylene derivatives.

摘要

通过锆介导的 1-炔基硼酸酯的区域和立体选择性双官能化反应，以及随后的钌催化的闭环复分解（RCM）反应，合成了新型环状 1-烯基硼酸酯。得到的取代环状 1-烯基硼酸酯可转化为邻三联苯和三联苯衍生物。