Kim Jwa-Kyung, Choi Sun Ryoung, Choi Myung Jin, Kim Sung Gyun, Lee Young Ki, Noh Jung Woo, Kim Hyung Jik, Song Young Rim
Department of Internal Medicine, Hallym University Sacred Heart Hospital, Anyang, Republic of Korea; Kidney Research Institute, Hallym University College of Medicine, Republic of Korea.
Department of Internal Medicine, Kangnam Sacred Heart Hospital, Seoul, Republic of Korea; Kidney Research Institute, Hallym University College of Medicine, Republic of Korea.
Clin Nutr. 2014 Feb;33(1):64-8. doi: 10.1016/j.clnu.2013.04.002. Epub 2013 Apr 8.
BACKGROUND & AIMS: We investigated the prevalence of sarcopenia in elderly patients with end-stage renal disease (ESRD) and its relationship with various markers of nutrition, cognitive function, depressive symptoms, inflammation and β2-microglobulin.
A cross-sectional study was conducted with 95 patients having ESRD aged over 50 years. Sarcopenia was defined as a decline in both muscle mass and strength.
The mean age was 63.9 ± 10.0 years; 56.8% were men and 52.6% had diabetes. Sarcopenia was highly prevalent in elderly patients with ESRD (37.0% in men and 29.3% in women). Subjective Global Assessment (SGA), inflammatory markers and β2-microglobulin levels were significantly associated with sarcopenia, even after adjustment for age, gender, diabetes, and body mass index. Additionally, patients with depressive symptoms showed a higher risk of sarcopenia relative to those without depressive symptoms (odds ratio, OR = 6.87, 95% confidence interval, CI = 2.06-22.96) and sarcopenia was more likely to be present in patients with mild cognitive dysfunction (OR = 6.35, 95% CI = 1.62-34.96).
Sarcopenia is highly prevalent in elderly patients with ESRD and is closely associated with SGA, inflammatory markers, β2-microglobulin, depression and cognitive dysfunction.
我们调查了终末期肾病（ESRD）老年患者中肌肉减少症的患病率及其与各种营养指标、认知功能、抑郁症状、炎症和β2-微球蛋白的关系。
对95名年龄超过50岁的ESRD患者进行了一项横断面研究。肌肉减少症定义为肌肉质量和力量均下降。
平均年龄为63.9±10.0岁；56.8%为男性，52.6%患有糖尿病。肌肉减少症在ESRD老年患者中非常普遍（男性为37.0%，女性为29.3%）。即使在调整了年龄、性别、糖尿病和体重指数后，主观全面评定（SGA）、炎症标志物和β2-微球蛋白水平仍与肌肉减少症显著相关。此外，有抑郁症状的患者相对于无抑郁症状的患者出现肌肉减少症的风险更高（优势比，OR = 6.87，95%置信区间，CI = 2.06 - 22.96），并且轻度认知功能障碍患者更易出现肌肉减少症（OR = 6.35，95%CI = 1.62 - 34.96）。
肌肉减少症在ESRD老年患者中非常普遍，并且与SGA、炎症标志物、β2-微球蛋白、抑郁和认知功能障碍密切相关。
