Sardi A, Nieroda C A, Siddiqi M A, Minton J P, Martin E W
Department of Surgery, Ohio State University of Medicine, Columbus.
Am Surg. 1990 Apr;56(4):255-9.
During the past 14 years, eight patients have undergone two or more major hepatic procedures in an attempt to control metastatic colon cancer confined to the liver. A total of 19 operations was performed. In all cases, a rising level of carcinoembryonic antigen was the main indicator for surgical intervention. There were no operative deaths. Major complications occurred in 15 per cent. Following the first hepatic intervention, two patients remain alive and free of disease at 43 and 47 months (56 and 100 months since diagnosis), respectively. In the six patients who have died, survival from the first hepatic intervention ranged from 17 to 38 months (median 27 months). Age, sex, location of primary, size of primary, interval from primary operation to second operation, and site of hepatic metastasis did not influence survival. In carefully selected patients with metastatic colon carcinoma confined to the liver, encouraging results can be obtained by performing multiple surgical procedures.
在过去14年中，8例患者接受了两次或更多次主要肝脏手术，试图控制局限于肝脏的转移性结肠癌。共进行了19次手术。在所有病例中，癌胚抗原水平升高是手术干预的主要指标。无手术死亡病例。主要并发症发生率为15%。首次肝脏干预后，两名患者分别在43个月和47个月（自诊断起56个月和100个月）时仍存活且无疾病。在6例死亡患者中，首次肝脏干预后的生存期为17至38个月（中位数27个月）。年龄、性别、原发灶位置、原发灶大小、从初次手术到二次手术的间隔时间以及肝转移部位均不影响生存期。对于精心挑选的局限于肝脏的转移性结肠癌患者，通过进行多次外科手术可获得令人鼓舞的结果。
