Department of Veterinary Disease Biology, Faculty of Health and Medical Sciences, University of Copenhagen, Stigbøjlen 4, 1870 Frederiksberg C, Denmark.
Vet Microbiol. 2013 Aug 30;165(3-4):373-7. doi: 10.1016/j.vetmic.2013.04.008. Epub 2013 Apr 12.
Salmonella enterica serotype Typhimurium (S. Typhimurium) can invade in the intestine of the avian host, and knowledge on the mechanisms that govern this is potentially important for prevention of disease. This study investigated the invasion of S. Typhimurium in the avian host and to which extent it depended on motility and chemotaxis. Wild type and previously well-characterized transposon mutants in flagella genes fliC and fljB and in chemotaxis genes cheA, cheB and cheR were used as challenge strains in intestinal loop experiments. Invasion was shown to be dose dependent, but did not require functional flagella or chemotaxis genes. In support of the results from intestinal loop experiments, flagella and chemotaxis genes were not significantly important to the outcome of an oral infection. The results showed that S. Typhimurium invasion in the avian host was dose dependent and was not affected by the loss of flagella and chemotaxis genes.
鼠伤寒沙门氏菌（S. Typhimurium）能够侵袭禽类宿主的肠道，了解控制这种侵袭的机制对于预防疾病可能非常重要。本研究调查了 S. Typhimurium 在禽类宿主中的侵袭情况，以及其在多大程度上依赖于运动性和趋化性。野生型和以前经过充分表征的鞭毛基因 fliC 和 fljB 以及趋化性基因 cheA、cheB 和 cheR 的转座子突变体被用作肠道环实验中的挑战菌株。结果表明，侵袭与剂量有关，但不需要功能性鞭毛或趋化性基因。肠道环实验的结果表明，鞭毛和趋化性基因对于口服感染的结果并不重要。结果表明，S. Typhimurium 在禽类宿主中的侵袭与剂量有关，不受鞭毛和趋化性基因缺失的影响。
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