Research Centre for Psychiatry and Behavioral Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.
Asian J Psychiatr. 2013 Jun;6(3):208-13. doi: 10.1016/j.ajp.2012.12.005. Epub 2013 Feb 8.
Bipolar disorder is one of ten most debilitating diseases in the world, leading to a lessened quality of life amongst its sufferers. This randomised control trial demonstrates the effectiveness of psycho-education intervention along with a patient support system in the management of this disorder.
In this trial, 108 patients, divided equally into two groups, were randomly assigned to receive either pharmacotherapy alone (control group) or psycho-education along with pharmacotherapy treatment (intervention group) for a two year period. Each individual patient in the "intervention" group received eight, fifty-minute sessions of psychological education, followed by monthly telephone follow-up care and psychological support in the subsequent 18 months. Each group was evaluated, once every 6 months for a period of 18 months, in the areas of "quality of life", "symptoms of relapse", "pharmacotherapy compliance" and "number of hospital admission for recurrence of bipolar disorder".
The result of this study indicates that patients in the "intervention" group had a statistically significant enhancement in medication compliance (P = 0.008). Regarding every aspect of life quality, this group was at a better position than the "control" group (P = 0.000). As to relapse and hospital admission, the "intervention" group reported much lower cases compared with the "control" group at a significance level of P = 0.000.
This research has demonstrated that in the psycho-education intervention group, there was a more significant improvement in all areas of quality of life, number of relapses, and hospitalization due to recurrence of bipolar disorder and medication compliance than it was evident in the control groups.
双相情感障碍是世界上十大致残疾病之一,导致患者的生活质量下降。这项随机对照试验表明,心理教育干预和患者支持系统在这种疾病的管理中是有效的。
在这项试验中,108 名患者被平均分为两组,随机分配接受单独药物治疗(对照组)或药物治疗联合心理教育(干预组),为期两年。干预组的每个个体患者都接受了八次五十分钟的心理教育课程,随后在接下来的 18 个月中每月进行电话随访和心理支持。每个组在 18 个月的时间内每 6 个月评估一次,评估领域包括“生活质量”、“复发症状”、“药物治疗依从性”和“因双相情感障碍复发而住院的次数”。
这项研究的结果表明,干预组患者在药物治疗依从性方面有统计学上的显著提高(P=0.008)。在生活质量的各个方面,该组都比对照组处于更好的位置(P=0.000)。至于复发和住院,干预组报告的病例明显低于对照组,差异具有统计学意义(P=0.000)。
这项研究表明,在心理教育干预组中,生活质量、复发次数和因双相情感障碍复发而住院的次数以及药物治疗依从性的所有方面都有更显著的改善,而对照组则没有明显改善。