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经皮肾去神经术作为难治性动脉高血压的一种新治疗方法

[Percutaneous renal denervation as a new method of treatment of resistant arterial hypertension].

作者信息

Mach-Jamińska Anna, Sułowicz Władysław

机构信息

Katedra i Klinika Nefrologii UJ CM.

出版信息

Przegl Lek. 2012;69(11):1215-9.

Abstract

The sympathetic nervous system plays an important role in the progression of arterial hypertension. This paper describes percutaneous renal denervation as a new, minimally invasive method of treating resistant hypertension. The procedure is based on ablation of the renal sympathetic nerves using radiofrequency energy after insertion of the Simplicity catheter into the renal artery. We discuss the indications and contraindications for renal artery denervation and describe the procedure itself. The results of large randomized trials such as Simplicity HTN-1 and HTN-2, are very promising. They show a significant decrease in blood pressure observed within 3 months after the denervation procedure, with few complications, without pathological effects on renal function. It is suggested that besides the impact on blood pressure, renal artery denervation can also improve carbohydrate metabolism, as well as sleep apnea and the treatment results of heart failure.

摘要

交感神经系统在动脉高血压的进展中起重要作用。本文将经皮肾去神经术描述为一种治疗顽固性高血压的新型微创方法。该手术是在将Simplicity导管插入肾动脉后,利用射频能量消融肾交感神经。我们讨论了肾动脉去神经术的适应证和禁忌证,并描述了手术过程本身。Simplicity HTN - 1和HTN - 2等大型随机试验的结果非常有前景。这些结果显示,去神经术后3个月内血压显著下降,并发症少,对肾功能无病理影响。有人认为,除了对血压的影响外,肾动脉去神经术还可以改善碳水化合物代谢,以及睡眠呼吸暂停和心力衰竭的治疗效果。

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