踝臂指数与颈动脉内膜中层厚度作为印度人严重冠状动脉粥样硬化替代标志物的诊断效用比较。
Comparison of diagnostic utilities of ankle-brachial index and carotid intima-media thickness as surrogate markers of significant coronary atherosclerosis in Indians.
作者信息
Ezhumalai Babu, Krishnasuri Subrahmanyam Dharanipragada, Jayaraman Balachander
机构信息
Senior Resident, Dept. of Cardiology, Jawaharlal Institute of Postgraduate Medical Education and Research, Dhanvantri Nagar, Gorimedu, Pondicherry 605006, India.
出版信息
Indian Heart J. 2013 Mar-Apr;65(2):137-41. doi: 10.1016/j.ihj.2013.02.011. Epub 2013 Feb 21.
AIM
We aimed to compare Ankle-brachial index (ABI) and Carotid intima-media thickness (CIMT) as surrogate markers of significant coronary atherosclerosis in South Indians with coronary artery disease (CAD).
METHODS AND RESULTS
There were two groups: CAD group (n = 59) and Control group (n = 55). Mean ABI (0.82 ± 0.06 vs. 1.16 ± 0.11, p < 0.0001) and mean CIMT (0.74 ± 0.22 mm vs. 0.45 ± 0.09 mm, p < 0.0001) were statistically different between two groups. ABI < 0.9 (sensitivity: 91.53%, specificity: 100%) and CIMT > 0.63 mm (sensitivity: 61.02%, specificity: 98.18%) implied significant CAD. ABI and CIMT were negatively correlated to one another. With increasing severity of CAD, ABI decreased but CIMT increased.
CONCLUSION
ABI and CIMT are simple noninvasive tools providing insight into coronary atherosclerosis. They can be done at bedside and easily repeated than coronary angiography. ABI < 0.9 is a better surrogate marker of significant coronary atherosclerosis than CIMT > 0.63 mm in South Indians with CAD.
目的
我们旨在比较踝臂指数（ABI）和颈动脉内膜中层厚度（CIMT），将其作为患有冠状动脉疾病（CAD）的南印度人严重冠状动脉粥样硬化的替代标志物。
方法与结果
分为两组：CAD组（n = 59）和对照组（n = 55）。两组间的平均ABI（0.82±0.06对1.16±0.11，p < 0.0001）和平均CIMT（0.74±0.22毫米对0.45±0.09毫米，p < 0.0001）存在统计学差异。ABI < 0.9（敏感性：91.53%，特异性：100%）和CIMT > 0.63毫米（敏感性：61.02%，特异性：98.18%）提示存在严重CAD。ABI和CIMT彼此呈负相关。随着CAD严重程度增加，ABI降低而CIMT升高。
结论
ABI和CIMT是提供冠状动脉粥样硬化相关信息的简单无创工具。它们可在床边进行，且比冠状动脉造影更容易重复操作。在患有CAD的南印度人中，ABI < 0.9比CIMT > 0.63毫米是更优的严重冠状动脉粥样硬化替代标志物。
Zotero 插件