英夫利昔单抗治疗银屑病继发的药物性狼疮和自身免疫性肝炎。
Drug-induced lupus and autoimmune hepatitis secondary to infliximab for psoriasis.
作者信息
Dang Lucy J, Lubel John S, Gunatheesan Shyamalar, Hosking Patrick, Su John
机构信息
Dermatology Department, Monash University, Australia; Eastern Health Clinical School, Monash University, Australia.
出版信息
Australas J Dermatol. 2014 Feb;55(1):75-9. doi: 10.1111/ajd.12054. Epub 2013 May 8.
We describe a case of previously unreported autoimmune hepatitis and lupus-like syndrome induced by infliximab treatment for chronic plaque psoriasis. The condition resolved after withdrawal of infliximab, with the liver injury having been reversed and minimal periportal fibrosis. In a two-part discussion we review the current literature on the pharmacology of infliximab and provide recommendations for management of infliximab side effects.
我们描述了一例由英夫利昔单抗治疗慢性斑块状银屑病引发的此前未报道过的自身免疫性肝炎和狼疮样综合征。停用英夫利昔单抗后病情得到缓解，肝损伤得以逆转，门周纤维化轻微。在一个分两部分的讨论中，我们回顾了目前关于英夫利昔单抗药理学的文献，并为英夫利昔单抗副作用的管理提供建议。
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