Shon Wonwoo, Wolz Michael M, Newman Catherine C, Bridges Alina G
Division of Dermatopathology and Cutaneous Immunopathology, Mayo Clinic, Rochester, Minnesota, USA; Department of Dermatology, Mayo Clinic, Rochester, Minnesota, USA.
Australas J Dermatol. 2014 Nov;55(4):e71-3. doi: 10.1111/ajd.12058. Epub 2013 May 8.
Reticulated acanthoma with sebaceous differentiation (RASD) represents a rare benign cutaneous epithelial neoplasm with sebaceous differentiation. There has been much speculation about the relationship between RASD and Muir-Torre syndrome (MTS). We report a 53 year-old man who presented with RASD in addition to a prior history of sebaceous adenomas. Immunohistochemically, the tumour cells in the RASD and sebaceous adenomas showed a significantly reduced MSH6 protein expression, whereas there was no loss of MLH1, MSH2 and PMS2. This benign neoplasm, which can be mistaken for various other cutaneous lesions with sebaceous differentiation, deserves wider recognition for its possible association with MTS.
具有皮脂腺分化的网状棘皮瘤（RASD）是一种罕见的具有皮脂腺分化的良性皮肤上皮肿瘤。关于RASD与穆尔-托雷综合征（MTS）之间的关系一直存在诸多猜测。我们报告一名53岁男性，除了既往有皮脂腺腺瘤病史外，还出现了RASD。免疫组化显示，RASD和皮脂腺腺瘤中的肿瘤细胞MSH6蛋白表达显著降低，而MLH1、MSH2和PMS2没有缺失。这种可被误诊为其他各种具有皮脂腺分化的皮肤病变的良性肿瘤，因其可能与MTS相关，值得更广泛的认识。
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