Okuyama Satoshi, Makihata Nahomi, Yoshimura Morio, Amakura Yoshiaki, Yoshida Takashi, Nakajima Mitsunari, Furukawa Yoshiko
Department of Pharmaceutical Pharmacology, College of Pharmaceutical Sciences, Matsuyama University, 4-2 Bunkyo-cho, Matsuyama, Ehime 790-8578, Japan.
Int J Mol Sci. 2013 May 7;14(5):9767-78. doi: 10.3390/ijms14059767.
Oenothein B has been recently evaluated for its ability to affect inflammatory responses in peripheral tissues. In this study, we examined its effect on the damage to the central nervous system due to systemic inflammation. For this purpose, ICR mice were injected with an intraperitoneal (i.p.) dose of lipopolysaccharide (LPS; 1 mg/kg mouse). When oenothein B was administered per os (p.o.), it suppressed (1) LPS-induced abnormal behavior in open field; (2) LPS-induced microglial activation in the hippocampus and striatum; and (3) LPS-induced cyclooxygenase (COX)-2 production in the hippocampus and striatum of these mice. These results suggest that oenothein B had the ability to reduce neuroinflammation in the brain during systemic inflammation.
最近对oenothein B影响外周组织炎症反应的能力进行了评估。在本研究中，我们检测了它对全身炎症引起的中枢神经系统损伤的影响。为此，给ICR小鼠腹腔注射脂多糖（LPS；1 mg/kg小鼠）。当经口给予oenothein B时，它抑制了：（1）LPS诱导的旷场试验中的异常行为；（2）LPS诱导的海马体和纹状体中的小胶质细胞激活；以及（3）LPS诱导的这些小鼠海马体和纹状体中环氧合酶（COX）-2的产生。这些结果表明，oenothein B具有减轻全身炎症期间大脑神经炎症的能力。
Zotero 插件
