Gibbs N M, Rodoreda P
West Australian Anaesthetic Mortality Committee, Government of Western Australia Department of Health, Royal Street, Western Australia, Australia.
Anaesth Intensive Care. 2013 May;41(3):302-10. doi: 10.1177/0310057X1304100305.
This paper reports on the causes and preventability of primary anaesthetic deaths in Western Australia between 1985 and 2008. In Western Australia, it is a legal requirement to report all deaths that occur within 48 hours of an anaesthetic and later deaths if an anaesthetic complication is implicated. A committee assesses whether an anaesthetic factor caused the death (a primary anaesthetic death) or contributed to the death (an anaesthesia-related death). Of the 2361 deaths reported to the Committee over the 24-year period, 102 were considered anaesthesia-related and of these, 53 were considered a primary anaesthetic death. There were six main causes of primary anaesthetic death: failure to oxygenate; aspiration of gastric contents; adverse drug reaction; dose-related drug effect leading to an adverse cardiovascular event; intravascular injection of local anaesthetic; and injury related to an anaesthetic procedure or invasive monitoring. The most common cause was a dose-related drug effect leading to an adverse cardiovascular event. The medical condition of the patient was considered a significant contributing factor in 69% of the deaths and 72% were considered preventable. In the second 12-year period, there were fewer deaths overall (15 vs 38), proportionately fewer deaths related to failure to oxygenate (one vs six) and proportionately more deaths related to aspiration of gastric contents (four vs two). However, the percentage of deaths considered preventable was similar. These findings can be used to advise patients on anaesthetic risks, to educate anaesthetists about preventable deaths and to encourage the development of even safer anaesthetic drugs and techniques.
本文报告了1985年至2008年间西澳大利亚州原发性麻醉死亡的原因及可预防性。在西澳大利亚州,法律要求报告所有在麻醉后48小时内发生的死亡事件,若涉及麻醉并发症,后期死亡事件也需报告。一个委员会会评估是否是麻醉因素导致了死亡(原发性麻醉死亡)或促成了死亡(与麻醉相关的死亡)。在这24年期间向该委员会报告的2361例死亡事件中,102例被认为与麻醉相关,其中53例被认为是原发性麻醉死亡。原发性麻醉死亡有六个主要原因:氧合失败;胃内容物误吸;药物不良反应;剂量相关的药物效应导致不良心血管事件;局部麻醉药血管内注射;以及与麻醉操作或侵入性监测相关的损伤。最常见的原因是剂量相关的药物效应导致不良心血管事件。69%的死亡病例中患者的病情被认为是一个重要的促成因素,72%的死亡被认为是可预防的。在第二个12年期间,总体死亡人数较少(15例对38例),与氧合失败相关的死亡比例相应减少(1例对6例),与胃内容物误吸相关的死亡比例相应增加(4例对2例)。然而,被认为可预防的死亡百分比相似。这些发现可用于向患者告知麻醉风险,教育麻醉师了解可预防的死亡,并鼓励研发更安全的麻醉药物和技术。