近期关于小儿心肌炎的临床与转化研究。
Recent clinical and translational research on pediatric myocarditis.
作者信息
Canter Charles E, Cunningham Madeleine W, Cooper Leslie T
机构信息
Division of Pediatric Cardiology, Department of Pediatrics, Washington University St. Louis, MO, One Children's Place, Department of Pediatrics St. Louis MO, 63110, Campus Box 8116-NWT, United States.
出版信息
Prog Pediatr Cardiol. 2011 Aug 1;32(1):15-18. doi: 10.1016/j.ppedcard.2011.06.004.
Myocarditis is one of the most common causes of a pediatric dilated cardiomyopathy phenotype. While pediatric myocarditis is generally associated with resolution of myocardial dysfunction, approximately 30% of pediatric myocarditis patients will die or undergo heart transplantation. Cardiac magnetic resonance imaging is increasingly being utilized as the primary diagnositic modality in adult myocarditis. Animal studies and adult experience suggest that autoimmunity may contribute to cardiac dysfunction in myocarditis. These adult findings have yet to be evaluated fully in children, but may have an impact on the diagnosis and treatment of pediatric myocarditis in the future. The recent availability of pediatric specific ventricular assist devices may offer the potential for long-term support to allow for a greater chance for myocardial recovery.
心肌炎是小儿扩张型心肌病表型最常见的病因之一。虽然小儿心肌炎通常与心肌功能障碍的缓解相关，但约30%的小儿心肌炎患者会死亡或接受心脏移植。心脏磁共振成像越来越多地被用作成人心肌炎的主要诊断方式。动物研究和成人经验表明，自身免疫可能导致心肌炎中的心脏功能障碍。这些成人研究结果尚未在儿童中得到充分评估，但未来可能会对小儿心肌炎的诊断和治疗产生影响。最近小儿专用心室辅助装置的出现可能为长期支持提供了潜力，从而为心肌恢复提供更大的机会。
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