Moratalla Charcos Luz Maria, Pastor Navarro Teresa, Cortes Vizcaino Virginia, Osca Garcia Jose Manuel, Gil Salom Manuel
Service of Urology, Hospital Universitario Dr. Peset, Valencia, Spain.
Arch Esp Urol. 2013 May;66(4):368-71.
To report a case of a neuroendocrine differentiation in a prostate cancer patient, a rare subtype.
We describe the case of a patient diagnosed with adenocarcinoma of the prostate initially, who presented hematuria due to disease progression with neuroendocrine differentiation despite androgen-deprivation therapy (ADT ).
Prostate cancer is the most common tumor in men. Histologically they are diagnosed as adenocarcinomas, which followed by ADT for a long time, develop neuroendocrine differentiation (NED ).
The prognostic significance of NED remains controversial. We must think in neuroendocrine differentiation in ADT-treated patient with disease progression and low PSA.
报告一例前列腺癌患者出现神经内分泌分化的病例，这是一种罕见的亚型。
我们描述了一名最初被诊断为前列腺腺癌的患者的病例，该患者尽管接受了雄激素剥夺治疗（ADT），但由于疾病进展并伴有神经内分泌分化而出现血尿。
前列腺癌是男性最常见的肿瘤。组织学上它们被诊断为腺癌，在长期接受ADT治疗后，会出现神经内分泌分化（NED）。
NED的预后意义仍存在争议。对于疾病进展且PSA水平低的接受ADT治疗的患者，我们必须考虑神经内分泌分化的情况。
