Aynali Giray, Ozkan Mustafa, Aynali Ayşe, Ceyhan Betül, Armağan Hakan, Yarıktaş Murat, Doğan Mustafa
Department of Otolaryngology, Medicine Faculty of Süleyman Demirel University, Isparta, Turkey.
Kulak Burun Bogaz Ihtis Derg. 2013 May-Jun;23(3):148-52. doi: 10.5606/kbbihtisas.2013.64426.
This study aims to evaluate the serum levels of hemoglobin, vitamin B12 and folic acid in patients with recurrent minor aphthous stomatitis.
Between June 2010 and January 2012, a total of 112 patients including 57 with recurrent aphthous stomatitis (study group; 30 males 27 females; mean age 36.7±13.9 years; range 13 to 74 years) and 45 with chronic tinnitus patients without recurrent aphthous stomatitis (control group; 18 males 27 females; mean age 39.7±15.1 years; range 20 to 80 years) who were admitted to our clinic were included in this study. The serum hemoglobin, vitamin B12 and folic acid levels of the patients were measured and statistically compared.
There was no significant difference in serum levels of hemoglobin and folic acid between the groups. Serum levels of vitamin B12 were significantly lower in the study group, compared to the control group (p<0.05). Serum levels of hemoglobin and folic acid were significantly lower in women compared to men in both groups (p<0.05).
Vitamin B12 deficiency, but not lower levels of folic acid and hemoglobin, may play a role in the underlying etiology of aphthous stomatitis. Vitamin B12 supplements may be added to the treatment of recurrent aphthous stomatitis.
本研究旨在评估复发性轻型阿弗他溃疡患者的血清血红蛋白、维生素B12和叶酸水平。
在2010年6月至2012年1月期间，共有112例患者纳入本研究，其中包括57例复发性口腔溃疡患者（研究组；男性30例，女性27例；平均年龄36.7±13.9岁；年龄范围13至74岁）和45例无复发性口腔溃疡的慢性耳鸣患者（对照组；男性18例，女性27例；平均年龄39.7±15.1岁；年龄范围20至80岁），这些患者均入住我们的诊所。对患者的血清血红蛋白、维生素B12和叶酸水平进行测量并进行统计学比较。
两组之间血清血红蛋白和叶酸水平无显著差异。与对照组相比，研究组的血清维生素B12水平显著降低（p<0.05）。两组中女性的血清血红蛋白和叶酸水平均显著低于男性（p<0.05）。
维生素B12缺乏而非叶酸和血红蛋白水平降低可能在阿弗他溃疡的潜在病因中起作用。复发性阿弗他溃疡的治疗中可添加维生素B12补充剂。
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