T 细胞中的 T-bet：在不同 T 细胞命运决定中的作用。
T-bet in the spot light: roles in distinct T-cell fate determination.
机构信息
Department of Surgery, University of Illinois College of Medicine, Peoria, IL, USA.
出版信息
Cell Mol Immunol. 2013 Jul;10(4):289-91. doi: 10.1038/cmi.2013.18. Epub 2013 May 20.
Abstract
The transcription factor T-bet was originally described to be important for the differentiation of the CD4(+) Th1 subset. More recent investigations implicate T-bet in the lineage commitment of a variety of innate immune cells also. The T-bet appears to have a dual role in the immune system. Under certain conditions T-bet provides a beneficial role, whereas the exaggerated expression of T-bet in certain innate lymphoid cells can be detrimental to the host. Therefore, this transcription factor needs to be carefully regulated. The feedback control and the epigenetic mechanisms involved in the expression of T-bet remain to be fully elucidated.
摘要
转录因子 T-bet 最初被描述为对 CD4(+) Th1 亚群的分化很重要。最近的研究表明，T-bet 也参与了多种固有免疫细胞的谱系分化。T-bet 在免疫系统中似乎具有双重作用。在某些情况下，T-bet 发挥有益作用，而某些固有淋巴细胞中 T-bet 的过度表达可能对宿主有害。因此，需要对这种转录因子进行精细调控。T-bet 表达涉及的反馈控制和表观遗传机制仍有待充分阐明。
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