轴向位置带有卤乙酸配体的铂（IV）前药可以在生物学相关条件下发生水解。
Platinum(IV) prodrugs with haloacetato ligands in the axial positions can undergo hydrolysis under biologically relevant conditions.
机构信息
Institute for Drug Research, School of Pharmacy, The Hebrew University of Jerusalem, Jerusalem, 91120, Israel.
出版信息
Angew Chem Int Ed Engl. 2013 Jun 3;52(23):6059-62. doi: 10.1002/anie.201300640. Epub 2013 May 17.
PMID:23686723
Abstract
Losing ligands rapidly: Pt(IV) complexes with haloacetato ligands can hydrolyze rapidly under biological conditions (pH 7 and 37 °C, see scheme) and the rate increases with increasing pH value. Possible mechanisms for this hydrolysis are examined using H2(18)O and ESI-MS analysis.
摘要
迅速失去配体
具有卤乙酸根配体的 Pt(IV) 配合物在生物条件下（pH 值为 7 和 37°C，见方案）可以迅速水解，并且随着 pH 值的增加水解速率增加。使用 H2(18)O 和 ESI-MS 分析来检查这种水解的可能机制。
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