一种用于制备水凝胶颗粒的新型气溶胶方法。
A Novel Aerosol Method for the Production of Hydrogel Particles.
作者信息
Guzman-Villanueva Diana, Smyth Hugh D C, Herrera-Ruiz Dea, El-Sherbiny Ibrahim M
机构信息
Facultad de Farmacia, Universidad Autónoma del Estado de Morelos, 62209 Cuernavaca MOR, Mexico ; Division of Pharmaceutics, College of Pharmacy, The University of Texas at Austin, Austin, TX 78712, USA.
出版信息
J Nanomater. 2011;2011(2011). doi: 10.1155/2011/507508.
A novel method of generating hydrogel particles for various applications including drug delivery purposes was developed. This method is based on the production of hydrogel particles from sprayed polymeric nano/microdroplets obtained by a nebulization process that is immediately followed by gelation in a crosslinking fluid. In this study, particle synthesis parameters such as type of nebulizer, type of crosslinker, air pressure, and polymer concentration were investigated for their impact on the mean particle size, swelling behavior, and morphology of the developed particles. Spherical alginate-based hydrogel particles with a mean particle size in the range from 842 to 886 nm were obtained. Using statistical analysis of the factorial design of experiment it was found that the main factors influencing the size and swelling values of the particles are the alginate concentration and the air pressure. Thus, it was demonstrated that the method described in the current study is promising for the generation of hydrogel particles and it constitutes a relatively simple and low-cost system.
开发了一种用于包括药物递送目的在内的各种应用的新型水凝胶颗粒生成方法。该方法基于通过雾化过程获得的喷雾聚合物纳米/微滴生产水凝胶颗粒，随后立即在交联流体中凝胶化。在本研究中，研究了雾化器类型、交联剂类型、气压和聚合物浓度等颗粒合成参数对所制备颗粒的平均粒径、溶胀行为和形态的影响。获得了平均粒径在842至886nm范围内的球形海藻酸盐基水凝胶颗粒。通过对实验的析因设计进行统计分析发现，影响颗粒尺寸和溶胀值的主要因素是海藻酸盐浓度和气压。因此，证明了本研究中描述的方法在生成水凝胶颗粒方面具有前景，并且它构成了一个相对简单且低成本的系统。
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