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甲状腺髓样癌的外科治疗策略:何时需要进行淋巴结清扫术?

Surgical approach to the management of medullary thyroid cancer: when is lymph node dissection needed?

机构信息

Department of Surgery, General Hospital of Karditsa, Karditsa, Greece. mixalislak @ gmail.com

出版信息

Oncology. 2013;84(6):350-5. doi: 10.1159/000351148. Epub 2013 May 14.

DOI:10.1159/000351148
PMID:23689063
Abstract

OBJECTIVE

Medullary thyroid cancer (MTC) is a rare and particularly aggressive type of thyroid cancer of neuroendocrine origin. It occurs in hereditary and sporadic forms and its aggressiveness is related to the clinical presentation and the type of RET mutation.

METHODS

In this article, we present the criteria, as reviewed in contemporary literature, regarding lymph node dissection and radical neck dissection in patients with either sporadic or hereditary MTC.

RESULTS

Early diagnosis and treatment remains the key to a 100% cure rate.

CONCLUSIONS

Routine central lymph node dissection is the minimum procedure recommended for all sporadic and hereditary MTCs. Routine lateral lymph node dissection on either side is necessary when lymph node metastases are found in the central neck compartment.

摘要

目的

甲状腺髓样癌(MTC)是一种罕见且极具侵袭性的神经内分泌来源的甲状腺癌。它有遗传性和散发性两种形式,其侵袭性与其临床表现和 RET 突变类型有关。

方法

本文回顾了当代文献中关于散发性或遗传性 MTC 患者的淋巴结清扫和根治性颈清扫的标准。

结果

早期诊断和治疗仍然是 100%治愈的关键。

结论

对于所有散发性和遗传性 MTC,常规中央淋巴结清扫是推荐的最小手术程序。当中央颈部区域发现淋巴结转移时,需要对双侧进行常规侧方淋巴结清扫。

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