Department of Medicinal and Applied Chemistry, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
Chem Commun (Camb). 2013 Jun 28;49(51):5784-6. doi: 10.1039/c3cc40661j.
A concise solid-phase synthesis of inverse poly(amidoamine) dendrons was developed. Upon introduction of AB2-type monomers, each dendron generation was constructed via one reaction. G2 to G5 dendrons were constructed in a peptide synthesizer in 93%, 89%, 82%, and 78% yields, respectively, within 5 days.
开发了一种简明的固相合成反聚酰胺-胺树枝状分子的方法。通过引入 AB2 型单体，每个树枝状分子代均通过一步反应构建。G2 到 G5 树枝状分子在肽合成仪中分别以 93%、89%、82%和 78%的收率，在 5 天内合成，产率较高。
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