Todosi Ana-Maria, Gavrilescu Mihaela-Mădălina, Aniţei Gabriela-Maria, Filip B, Scripcariu V
University of Medicine and Pharmacy Grigore T Popa lasi, Faculty of Medicine.
Rev Med Chir Soc Med Nat Iasi. 2012 Oct-Dec;116(4):1106-11.
Colorectal cancer (CRC) is the third form of cancer in both men and women. In Romania, the incidence of CRC in 2000 is 17.74 %ooo, in 2002 becoming the second cause of death. We reviewed a series of studies that are related to colon cancer and studied the epithelial-mesenchymal transition at the front of tumor invasion (EMT). Cellular phenotypic changes characteristic of EMT can be induced by the absence of transition cofactor (p300) involved in cellular regulation. Loss of syndecan-l marker is associated with local tumor stage and metastasis. Modulators of protein kinase resistance was associated with changes in genes involved in EMT (including vimentin hyperexpression) and genes involved in invasion (N-cadherin) with a decrease expression of genes involved in epithelial cell adhesion (E-cadherin). Progression in colon cancer is characterized by activating mutations in Ras genes and tumor growth factor action. Vimentin expression associated with EMT initiates molecular program. One of the characteristics of EMT is the loss of E-cadherin. TGF-p (transforming growth factor beta) induces epithelial-mesenchymal transition in colon cancer cell lines with the microsatellite stability, inducing cell invasion and migration. EMT is a critical early event involved in invasion and metastasis of colorectal cancer, characterized by the presence of markers specific to each phenotype, epithelial or mesenchymal. Multiple biomarkers involved in the induction of EMT may represent future therapeutic target in the treatment of colonic neoplasia.
结直肠癌（CRC）是男性和女性中第三大癌症类型。在罗马尼亚，2000年CRC的发病率为17.74/10万，到2002年成为第二大致死原因。我们回顾了一系列与结肠癌相关的研究，并研究了肿瘤侵袭前沿的上皮-间质转化（EMT）。EMT特征性的细胞表型变化可由参与细胞调节的转化辅因子（p300）缺失诱导。Syndecan-1标志物的缺失与局部肿瘤分期和转移相关。蛋白激酶抗性调节剂与EMT相关基因（包括波形蛋白高表达）和侵袭相关基因（N-钙黏蛋白）的变化有关，同时上皮细胞黏附相关基因（E-钙黏蛋白）表达降低。结肠癌的进展以Ras基因的激活突变和肿瘤生长因子作用为特征。与EMT相关的波形蛋白表达启动分子程序。EMT的特征之一是E-钙黏蛋白的缺失。转化生长因子β（TGF-β）在具有微卫星稳定性的结肠癌细胞系中诱导上皮-间质转化，促进细胞侵袭和迁移。EMT是结直肠癌侵袭和转移过程中的一个关键早期事件，其特征是存在上皮或间质每种表型特有的标志物。参与诱导EMT的多种生物标志物可能代表结肠癌治疗的未来治疗靶点。
