Section of Men's Health, Aging and Metabolism, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Endocrinol Metab Clin North Am. 2013 Jun;42(2):255-70. doi: 10.1016/j.ecl.2013.02.012. Epub 2013 Apr 6.
Aging in men is associated with a decrease in serum testosterone levels due to attrition in testicular Leydig cells and slowing of the hypothalamic GnRH pulse generator. The practicing endocrinologist is frequently consulted for consideration of testosterone therapy in older men with late-onset hypogonadism (LOH), a condition that many clinicians fail to distinguish from organic hypogonadism. Recent data using syndromic definition show that only 2% of 40-80-year-old men have LOH. Co-morbidities and obesity strongly contribute to LOH, suggesting that testosterone is a biomarker of health. Hence, prevention and treatment of these co-morbidities might attenuate age-related decline in androgen levels.
男性衰老与血清睾丸酮水平下降有关，这是由于睾丸 Leydig 细胞耗竭和下丘脑 GnRH 脉冲发生器速度减慢所致。由于许多临床医生无法将迟发性性腺功能减退症（LOH）与器质性性腺功能减退症区分开来，因此经常有内分泌科医生被咨询是否对老年男性进行睾丸酮治疗。最近使用综合征定义的数据表明，只有 2%的 40-80 岁男性患有 LOH。合并症和肥胖强烈促成 LOH，这表明睾丸酮是健康的生物标志物。因此，预防和治疗这些合并症可能会减轻与年龄相关的雄激素水平下降。
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