Cox Associates, LLC, Denver, CO 80218, USA.
Regul Toxicol Pharmacol. 2013 Aug;66(3):336-46. doi: 10.1016/j.yrtph.2013.05.006. Epub 2013 May 21.
Recent studies have indicated that reducing particulate pollution would substantially reduce average daily mortality rates, prolonging lives, especially among the elderly (age ≥ 75). These benefits are projected by statistical models of significant positive associations between levels of fine particulate matter (PM2.5) levels and daily mortality rates. We examine the empirical correspondence between changes in average PM2.5 levels and temperatures from 1999 to 2000, and corresponding changes in average daily mortality rates, in each of 100 U.S. cities in the National Mortality and Morbidity Air Pollution Study (NMMAPS) data base, which has extensive PM2.5, temperature, and mortality data for those 2 years. Increases in average daily temperatures appear to significantly reduce average daily mortality rates, as expected from previous research. Unexpectedly, reductions in PM2.5 do not appear to cause any reductions in mortality rates. PM2.5 and mortality rates are both elevated on cold winter days, creating a significant positive statistical relation between their levels, but we find no evidence that reductions in PM2.5 concentrations cause reductions in mortality rates. For all concerned, it is crucial to use causal relations, rather than statistical associations, to project the changes in human health risks due to interventions such as reductions in particulate air pollution.
最近的研究表明,减少颗粒物污染将大大降低平均每日死亡率,延长寿命,尤其是在老年人(年龄≥75 岁)中。这些好处是通过统计模型预测的,这些模型显示细颗粒物(PM2.5)水平与每日死亡率之间存在显著的正相关关系。我们研究了 1999 年至 2000 年间美国国家死亡率和发病率空气污染研究(NMMAPS)数据库中 100 个城市的平均 PM2.5 水平和温度变化与平均每日死亡率变化之间的经验对应关系,该数据库具有这些 2 年的广泛的 PM2.5、温度和死亡率数据。正如之前的研究预期的那样,平均每日气温的升高似乎显著降低了平均每日死亡率。出乎意料的是,PM2.5 的减少似乎并没有导致死亡率的降低。PM2.5 和死亡率在寒冷的冬季都会升高,导致它们的水平之间存在显著的正统计关系,但我们没有发现证据表明 PM2.5 浓度的降低会导致死亡率的降低。对于所有相关人员来说,使用因果关系而不是统计关联来预测由于减少颗粒物空气污染等干预措施导致的人类健康风险的变化至关重要。