Kumar Gunjan, Kaur Darshpreet, Aggarwal Puneet, Khurana Tilak
Department of Internal Medicine, PGIMER, Dr Ram Manohar Lohia Hospital, New Delhi, India.
BMJ Case Rep. 2013 May 23;2013:bcr2013009220. doi: 10.1136/bcr-2013-009220.
Metabolic dysfunction in hypoparathyroidism is an important cause of intracranial calcifications, which cause cognitive impairment depending on the calcified areas leading to difficulties in executing activities of daily living. We report a case of a 25-year-old man who presented with gradually decreasing organisational skills, memory problems and difficulty in carrying out daily activities. CT imaging of the brain showed extensive calcification in the basal ganglia and cerebral white matter. Comprehensive health-related quality of life and cognitive assessment revealed significant affliction in his activities of daily living along with impairment in recall memory, executive functions and verbal fluency. Owing to late diagnosis, chronicity of cognitive problems could not prevent him from discontinuing his college education.
甲状旁腺功能减退症中的代谢功能障碍是颅内钙化的重要原因,颅内钙化会根据钙化区域导致认知障碍,进而导致日常生活活动执行困难。我们报告一例25岁男性病例,该患者出现组织能力逐渐下降、记忆问题以及日常生活活动困难。脑部CT成像显示基底神经节和脑白质广泛钙化。全面的健康相关生活质量和认知评估显示,他在日常生活活动中存在严重困扰,同时回忆记忆、执行功能和语言流畅性受损。由于诊断延迟,认知问题的慢性化未能阻止他中断大学学业。