不同的系统发育特征和降低的甘露糖敏感黏附能力是 IgA 缺陷个体中共生大肠杆菌的特征。

Different phylogenetic profile and reduced mannose-sensitive adherence capacity characterize commensal Escherichia coli in IgA deficient individuals.

机构信息

Institution for Biomedicine, Department of Infectious Disease, University of Gothenburg, Gothenburg, Sweden.

出版信息

Microb Pathog. 2013 Aug-Sep;61-62:62-5. doi: 10.1016/j.micpath.2013.05.007. Epub 2013 May 25.

DOI:10.1016/j.micpath.2013.05.007

PMID:23711964

Abstract

In IgA deficiency, secretory IgA (S-IgA) is absent from intestinal secretions. S-IgA carbohydrate chains act as receptors for the mannose specific (MS) adhesin fim of Escherichia coli. In IgA deficient (IgAd) individuals, commensal E. coli express less MS adherence to epithelial cells, due both to reduced carriage of the fimH adhesin gene, reduced capacity to switch it on, and reduced adherence of adhesin-expressing bacteria. Here, we show that commensal E. coli microbiota of IgA deficient individuals belong to phylogenetic group A and display low MS adherence. In healthy individuals, group B2 with strong MS adherence dominate.

摘要

在 IgA 缺乏症中，分泌型 IgA（S-IgA）不存在于肠道分泌物中。S-IgA 糖链作为大肠杆菌甘露糖特异性（MS）黏附素 fim 的受体。在 IgA 缺乏（IgAd）个体中，由于 fimH 黏附素基因携带减少、开启能力降低以及黏附表达细菌的黏附能力降低，共生大肠杆菌表达的 MS 黏附上皮细胞减少。在这里，我们表明 IgA 缺乏个体的共生大肠杆菌菌群属于 A 群，并且显示出低 MS 黏附性。在健康个体中，具有强 MS 黏附性的 B2 组占主导地位。