Patnayak R, Jena A, Parthasarathy S, Prasad P D, Reddy M K, Chowhan A K, Rukamangadha N, Phaneendra B V
Department of Pathology, Sri Venketeswar Institute of Medical Sciences, Tirupati, Andhra Pradesh 517 507, India.
Indian J Cancer. 2013 Jan-Mar;50(1):41-5. doi: 10.4103/0019-509X.112298.
Extra gastrointestinal stromal tumors (EGIST) are uncommon compared to their gastrointestinal counterparts. EGISTs involve omentum, mesentery, retroperitoneum, pancreas, and pelvis.
Ten EGISTs were analyzed in this study from January 1995 to November 2011. They were analyzed with respect to clinical features, imageological, histopathological, and immunohistochemical findings. The immunohistochemical stains used were Smooth muscle actin (SMA), Desmin, S-100 protein, CD34 and CD-117.
There was slight female preponderance with wide age range. Four of the tumors were in retroperitoneum, three in mesentery, and two in omentum and one in pelvis. Histopathologically majority were spindle cell tumors. Immunohistochemically CD117 was consistently positive followed by CD34. Smooth muscle actin was positive in eight cases, S-100 protein and desmin were positive in two cases each.
EGISTs are rare and should be considered in the differential diagnosis of the mesenchymal tumors and immunohistochemistry helps to confirm the diagnosis. Further study with better follow-up is desired to characterize these uncommon tumors.
与胃肠道间质瘤相比，胃肠道外间质瘤（EGIST）并不常见。EGIST可累及大网膜、肠系膜、腹膜后、胰腺和盆腔。
本研究分析了1995年1月至2011年11月期间的10例EGIST。对其临床特征、影像学、组织病理学和免疫组化结果进行了分析。所使用的免疫组化染色包括平滑肌肌动蛋白（SMA）、结蛋白、S-100蛋白、CD34和CD-117。
女性略占优势，年龄范围较广。4例肿瘤位于腹膜后，3例位于肠系膜，2例位于大网膜，1例位于盆腔。组织病理学上大多数为梭形细胞瘤。免疫组化方面，CD117始终呈阳性，其次是CD34。平滑肌肌动蛋白在8例中呈阳性，S-100蛋白和结蛋白在各2例中呈阳性。
EGIST罕见，在间叶性肿瘤的鉴别诊断中应予以考虑，免疫组化有助于确诊。需要进行更长期随访的进一步研究以明确这些罕见肿瘤的特征。
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