氟哌啶醇治疗躁狂症的剂量与血药浓度
Dose and blood levels of haloperidol in treatment of mania.
作者信息
Rifkin A, Karajgi B, Doddi S, Cooper T
机构信息
Department of Psychiatry, Queens Hospital Center Affiliation of Hillside Hospital, Long Island Jewish Medical Center, Glen Oaks, NY.
出版信息
Psychopharmacol Bull. 1990;26(1):144-6.
PMID:2371369
Abstract
Three doses of haloperidol, 10 mg/day, 30 mg/day, and 80 mg/day, were compared in 47 newly admitted manic patients. There was no difference in outcome within 6 weeks among the three doses. Four blood levels of plasma and red blood cell (RBC) haloperidol and reduced haloperidol showed no linear or curvilinear relationships to clinical response.
摘要
在47名新入院的躁狂症患者中比较了三种剂量的氟哌啶醇，分别为每天10毫克、30毫克和80毫克。在6周内，三种剂量的治疗结果没有差异。血浆和红细胞（RBC）中氟哌啶醇及还原氟哌啶醇的四种血药浓度与临床反应均无线性或曲线关系。
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