可手术治愈的直肠癌和乙状结肠远端癌的术前与术后辅助放疗

Preoperative versus postoperative adjuvant radiotherapy for surgically curable carcinoma of the rectum and distal sigmoid colon.

作者信息

Rahman S M, McKibben B T, Hardy T G, Schloss C D, Cho C C, Hartmann R F, Aguilar P S, Khanduja K S, Stewart W R

机构信息

Department of Radiotherapy, Grant Medical Center, Columbus, OH 43215.

出版信息

South Med J. 1990 Jul;83(7):774-7. doi: 10.1097/00007611-199007000-00014.

DOI:10.1097/00007611-199007000-00014

PMID:2371600

Abstract

From January 1979 to October 1986, 86 patients with surgically resectable adenocarcinoma of the rectum or rectosigmoid were treated with adjuvant radiotherapy consisting of preoperative 2,400 cGy (22 patients), preoperative 4,000 cGy (14 patients), "sandwich" technique (27 patients), and postoperative irradiation (23 patients). Average follow-up was 42.9 months. The local recurrence rate was 4.5%, 9.1%, 7.4%, and 34.8%, respectively. The distant metastasis rate was 18.2%, 18.2%, 7.4%, and 30.4%, respectively. Preoperative radiotherapy with adequate surgical resection appears more effective in reducing the incidence of local recurrence.

摘要

1979年1月至1986年10月，86例可手术切除的直肠或直肠乙状结肠腺癌患者接受了辅助放疗，包括术前2400 cGy（22例患者）、术前4000 cGy（14例患者）、“三明治”技术（27例患者）和术后放疗（23例患者）。平均随访时间为42.9个月。局部复发率分别为4.5%、9.1%、7.4%和34.8%。远处转移率分别为18.2%、18.2%、7.4%和30.4%。术前放疗联合充分的手术切除似乎在降低局部复发率方面更有效。