颗粒细胞瘤：37例研究
Granulosa cell tumours: a study of 37 cases.
作者信息
Nirmala C, Dave Kalpana S, Chauhan Anjana, Bhansali Ronak P, Arora Ruchi
机构信息
Gujarat Cancer and Research Institute, New Civil Hospital Campus, Asarva, Ahmedabad, 380016 India ; No. 91, III Cross, New Timber Yard Layout, Telecom Colony, Bangalore, 560026 India.
出版信息
J Obstet Gynaecol India. 2012 Jun;62(3):322-6. doi: 10.1007/s13224-012-0224-y. Epub 2012 Aug 1.
OBJECTIVES
To evaluate the clinico-pathological features, surgical procedures and postoperative treatment and their relation to survival in women with granulosa cell tumours.
METHODS
Data of 37 women with granulosa cell tumours were collected and reviewed retrospectively. Mann-Whitney test, log rank test and Kaplan-Meier survival analysis were applied appropriately.
RESULTS
Thirty-seven women of median age 48.6 years were diagnosed in stage Ia (45.9 %), stage Ic (27 %), stage III (16.2 %) and unstaged (10.8 %). The median follow up was 5 years. Overall survival was 93 % at 5 years. Disease-free survival at 5 years was 63 %. Tumour stage and residual disease were associated with poor prognosis (p < 0.001). Mitotic rate and tumour grade were not of prognostic significance.
CONCLUSIONS
Stage of disease and residual disease are valuable prognostic factors. Prospective studies with large sample sizes and long-term follow up are needed to confirm our findings.
目的
评估颗粒细胞瘤女性患者的临床病理特征、手术方式、术后治疗及其与生存的关系。
方法
回顾性收集并分析37例颗粒细胞瘤女性患者的数据。适当应用曼-惠特尼检验、对数秩检验和Kaplan-Meier生存分析。
结果
37例患者的中位年龄为48.6岁，分期为Ia期（45.9%）、Ic期（27%）、III期（16.2%）和未分期（10.8%）。中位随访时间为5年。5年总生存率为93%。5年无病生存率为63%。肿瘤分期和残留病灶与预后不良相关（p<0.001）。有丝分裂率和肿瘤分级无预后意义。
结论
疾病分期和残留病灶是重要的预后因素。需要进行大样本量和长期随访的前瞻性研究来证实我们的发现。
Zotero 插件