[恶性和非恶性前列腺组织中的血管内皮生长因子：与前列腺切除术后一年肿瘤复发的关联]
[Vascular endothelial growth factor in malignant and non malignant prostatic tissue: Association with tumor recurrence at one year after prostatectomy].
作者信息
Acuña Pedro, Ellwanger Andrés, Ramírez Angela, Cardemil Felipe, Vega Jorge, Casalino Renato, Madrid Eva
机构信息
Departamento de Urología, Corporación Nacional del Cáncer, Valparaíso, Chile.
出版信息
Rev Med Chil. 2013 Feb;141(2):153-9. doi: 10.4067/S0034-98872013000200002.
BACKGROUND
Prostate cancer (PC) is the second cause of death by cancer in men in Chile. Its behavior is so variable that it is necessary to search reliable prognostic markers. Vascular Endothelial Growth Factor (VEGF) is one of the most powerful pro-angiogenic factors. There is no agreement on its validity as a diagnostic or prognostic factor.
AIM
To search for VEFG in prostatic tissue.
MATERIAL AND METHODS
This study was performed in prostatectomy tissue coming from 41 patients with PC and 39 patients with benign prostatic hyperplasia (BPH). Specimens were studied using immunohistochemical staining for VEGF. The percentage of stained glandular cells per patient was calculated and associated with pathological diagnosis in cancer patients.
RESULTS
PC biopsies had a mean of 82% of VEGF (+) stained cells, while BPH had only 1.6% (p < 0.01). No relationship was found between the percentage of staining and recurrence at one year of follow-up in the case of PC.
CONCLUSIONS
These results would rule out VEGF as a prognostic factor in this series of patients.
背景
前列腺癌（PC）是智利男性癌症死亡的第二大原因。其行为变化很大，因此有必要寻找可靠的预后标志物。血管内皮生长因子（VEGF）是最强大的促血管生成因子之一。关于其作为诊断或预后因子的有效性尚无定论。
目的
在前列腺组织中寻找VEGF。
材料与方法
本研究对41例前列腺癌患者和39例良性前列腺增生（BPH）患者的前列腺切除组织进行。使用VEGF免疫组织化学染色对标本进行研究。计算每位患者染色腺细胞的百分比，并将其与癌症患者的病理诊断相关联。
结果
前列腺癌活检标本中VEGF（+）染色细胞的平均比例为82%，而BPH仅为1.6%（p<0.01）。在前列腺癌患者中，染色百分比与随访一年时的复发之间未发现相关性。
结论
这些结果将排除VEGF作为该系列患者的预后因子。
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